HCID 18446590, compound → HCID 18446591, compound

Participants

Reaction Steps

In a similar manner as described in Example 25 from 2-(5-bromo-2-furyl)-7-chloropyrazolo[1,5-a]pyridine-3-carbaldehyde (2.54 g, 7.8 mmol) was obtained 1-[2-(5-bromo-2-furyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol. To the solution of 1-[2-(5-bromo-2-furyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol in dichloromethane was added manganese dioxide as described in example 25. 1-[2-(5-Bromo-2-furyl)-7-chloropyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-one (0.86 g, two steps 32%) was obtained as a yellow solid. 1H NMR (CDCl3): δ 8.53 (d, 1H), 7.52–7.48 (m, 2H), 7.22 (d, 1H), 6.51 (d, 1H), 3.36 (s, 1H). MS m/z 349 (M+1).

Provenance & Evidence