HCID 18446592, compound → HCID 18446593, compound

Participants

Reaction Steps

A solution of 1-[3-(2-fluoro-4-pyridinyl)pyrazolo[1,5-a]pyridin-2-yl]ethanol (0.1 g, 0.4 mmol), manganese(IV)oxide (0.17 g. 1.95 mmol), and methylene chloride (10 mL) were allowed to stir at room temperature for 72 hours. When judged to be complete, the mixture was filtered through a plug of Celite, and the filtrate was concentrated to provide 1-[3-(2-fluoro-4-pyridinyl)pyrazolo[1,5-a]pyridin-2-yl]ethanone (97 mg, 98%) as a pale yellow solid. 1H NMR (DMSO-d6): δ 8.92 (d. 1H), 8.30 (d, 1H), 7.82 (d, 1H), 7.46 (m, 2H), 7.34 (s, 1H), 7.23 (m, 1H), 2.71 (s, 3H).

Provenance & Evidence