反应详情

To a solution of 5-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine (Prep61, 600 mg, 2.5 mmol) in MeOH (40 mL) 2N HClaq (10 mL) was added. After refluxing the mixture for 3 hours, the solvents were evaporated. The crude was triturated with acetone and filtered to give 480 mg of 5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione as a light brown powder (92% yield)

1. temperatureAfter refluxing the mixture for 3 hours
2. customthe solvents were evaporated
3. customThe crude was triturated with acetone
4. filtrationfiltered