Ethylene Oxide → HCID 72803002, compound

HRID 1269116Notes

Reaction equation

[CH3:1][CH:2]([CH3:26])[CH:3]([NH:15][C:16]([CH:18]1[CH:21]([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:20][NH:19]1)=[O:17])[CH:4]1[CH:9]([OH:10])[CH:8]([OH:11])[CH:7]([OH:12])[CH:6]([S:13][CH3:14])[O:5]1.[CH2:27]1[O:29][CH2:28]1>>[CH3:1][CH:2]([CH3:26])[CH:3]([NH:15][C:16]([CH:18]1[CH:21]([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:20][N:19]1[CH2:27][CH2:28][OH:29])=[O:17])[CH:4]1[CH:9]([OH:10])[CH:8]([OH:11])[CH:7]([OH:12])[CH:6]([S:13][CH3:14])[O:5]1

Participants

Reactant 2

HCID 6354Ethylene Oxide

HCID 72777238HCID 72777238, compound

Product 1

HCID 72803002HCID 72803002, compound

Procedure

A sample of 3-Butyl-azetidine-2-carboxylic acid [2-methyl-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide prepared in example 70 was alkylated with ethyleneoxide as depicted in scheme 12 (R6=2-hydroxyethyl) to provide the title compound.

Sources & evidence

ORD record: ord-939af16df8f04835b001764a839e96cc
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199105B2

Reaction notes

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