Benzoyl chloride → HCID 70565138, compound

Participants

Reaction Steps

A solution of trans-1-cyclohexyl-4-methylamino-3-pyrrolidinol (19.8 g) in 200 ml of methylene chloride was cooled to 5° C. and 20 g of powdered, anhydrous potassium carbonate was added. The mixture was stirred and cooled while 14.1 g of benzoyl chloride in 100 ml of methylene chloride was added dropwise. The mixture was allowed to come to room temperature and stirred for 24 hr., then heated at reflux for 5 hrs. The mixture was cooled and extracted with water. The methylene chloride was evaporated and the residue was converted to the hydrochloride and recrystallized twice from isopropyl alcohol, m.p. 184°-186.5° C.

Provenance & Evidence