HCID 70563983, compound → HCID 70565496, compound

Participants

Reaction Steps

A solution of 44 g of trans-N-(1-cyclohexyl-4-hydroxy-3-pyrrolidinyl)-N-methyl-4-nitrobenzamide in 600 ml of absolute ethanol was treated with a catalytic amount of platinum oxide and shaken in the Parr apparatus under hydrogen for one hour. The suspension was filtered and the filtrate evaporated under vacuum. The residue crystallized from a benzene-cyclohexane mixture and was recrystallized from toluene. The yield was 39.6 g (99%); m.p. 180.0°-182.5° C.

Provenance & Evidence