2-(4-Chlorophenyl)-2-methylpropionic acid → 2-(4-chlorophenyl)-2-methyl-N-(3-{4-[3-(propionylamino)phenyl]-1-piperidinyl}propyl)propanamide

Participants

Reaction Steps

Prepared according to the general procedure outlined in Scheme 10 using 2-(4-chlorophenyl)-2-methylpropanoic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}propanamide: 1H NMR (400 MHz, CDCl3) δ 7.86 (s, 1H), 7.50 (s, 1H), 7.34–7.19 (m, 6H), 6.96 (d, 1H, J=7.8 Hz), 6.72–6.67 (m, 1H), 3.42 (q, 2H, J=7.1 Hz), 3.31 (q, 3H, J=5.4 Hz), 2.49–2.35 (m, 5H), 2.08–1.95 (m, 2H), 1.82–1.74 (m, 2H), 1.71–1.62 (m, 3H), 1.56 (s, 6H), 1.24 (t, 3H, J=7.8 Hz); ESMS m/e: 470.3 [M+H]+.

Provenance & Evidence