HCID 70565610, compound → HCID 70564912, compound

Participants

Reaction Steps

A solution of 14 g (49.5 mmoles) of trans-4-chloro-N-(1-ethyl-4-hydroxy-3-pyrrolidinyl)-N-methylbenzamide in 150 ml of absolute ethanol was treated with ca. 0.5 g of palladium-on-charcoal catalyst and was shaken with hydrogen at 60° C. in the Parr reduction apparatus for 3 hr. The mixture was cooled and filtered and the filtrate was concentrated. The residue crystallized when it was stirred with 3:1 diethyl ether-acetone. Separation of the precipitate gave 13.7 g (97%) of white powder; m.p. 160°-163° C.

Provenance & Evidence