HCID 336796, compound → HCID 16755971, compound

HRID 1269189Notes

Reaction equation

HRID 1269189 reaction equation
[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:22][CH2:23][CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([C:32]2[CH:33]=[C:34]([NH:38][C:39](=[O:43])[CH:40]([CH3:42])[CH3:41])[CH:35]=[CH:36][CH:37]=2)[CH2:28][CH2:27]1>>[C:39]([NH:38][C:34]1[CH:33]=[C:32]([CH:29]2[CH2:30][CH2:31][N:26]([CH2:25][CH2:24][CH2:23][NH:22][C:8](=[O:10])[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH2:27][CH2:28]2)[CH:37]=[CH:36][CH:35]=1)(=[O:43])[CH:40]([CH3:42])[CH3:41]

Participants

3

Reactant 2

HCID 336796HCID 336796, compoundHCID 16757470N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamide

Product 1

HCID 16755971HCID 16755971, compound

Procedure

Example 11 was prepared from 2,2-diphenyl heptanoic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide according to the procedures described in Scheme 9: 1H NMR (400 MHz, CDCl3) δ 7.65 (s, 1H), 7.45 (s, 1H), 7.40 (m, 1H), 7.37–7.19 (m, 11H), 6.88 (d, 1H, J=7.3 Hz), 6.34 (t, 1H, J=4.5 Hz), 3.34–3.27 (m, 3H), 2.94–2.87 (m, 2H), 2.52 (septet, 1H, J=6.9 Hz), 2.46–2.34 (m, 4H), 2.27 (t, 2H, J=6.9 Hz), 2.00–1.91 (m, 2H), 1.77–1.69 (m, 2H), 1.69–1.52, (m, 5H), 1.30–1.20 (m, 12H); ESMS m/e: 568.4 (M+H)+.

Sources & evidence

ORD record
ord-ebdfce818e7b412893da414562edbd78
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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