2-Phenyl-2-(2,4,6-trimethylphenyl)acetic acid → N-[3-(1-{3-[(2-mesityl-2-phenylacetyl)amino]propyl}-4-piperidinyl)phenyl]propanamide

HRID 1269192Notes

Reaction equation

HRID 1269192 reaction equation
[C:1]1([CH3:19])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[CH:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:10](O)=[O:11].[NH2:20][CH2:21][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][CH:27]([C:30]2[CH:31]=[C:32]([NH:36][C:37](=[O:40])[CH2:38][CH3:39])[CH:33]=[CH:34][CH:35]=2)[CH2:26][CH2:25]1>>[C:1]1([CH3:19])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[CH:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:10]([NH:20][CH2:21][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][CH:27]([C:30]2[CH:31]=[C:32]([NH:36][C:37](=[O:40])[CH2:38][CH3:39])[CH:33]=[CH:34][CH:35]=2)[CH2:26][CH2:25]1)=[O:11]

Participants

3

Reactant 2

HCID 2312012-Phenyl-2-(2,4,6-trimethylphenyl)acetic acidHCID 21957142N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}propanamide

Product 1

HCID 21957246N-[3-(1-{3-[(2-mesityl-2-phenylacetyl)amino]propyl}-4-piperidinyl)phenyl]propanamide

Procedure

Example 14 was prepared from mesityl(phenyl) acetic acid and N-{3-[1-(3-aminopropyl) 4-piperidinyl]phenyl}propanamide according to the procedures described in Scheme 9: ESMS m/e: 526.3 (M+H)+.

Sources & evidence

ORD record
ord-8c16da7c256247daa53748ffd4705983
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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