2,2-Diphenylacetyl chloride → HCID 21957152, compound

Participants

Reaction Steps

Example 19 was prepared from diphenylacetyl chloride and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-3,3-dimethylbutanamide according procedures described in Scheme 8: 1H NMR (400 MHz, CDCl3) δ 10.73–10.50 (br, 1H), 8.63–8.48 (m, 1H), 7.97–7.77 (br, 1H), 7.70 (d, 1H, J=7.2 Hz), 7.45–7.11 (m, 11H), 6.89 (d, 1H, J=7.2 Hz), 5.01 (s, 1H), 3.46–3.26 (m, 4H), 2.97–2.77 (m, 2H), 2.77–2.50 (m, 3H), 2.42–2.17 (m, 2H), 2.25 (s, 2H), 2.14–1.94 (m, 2H), 1.93–1.78 (m, 2H), 1.00 (s, 9H); ESMS m/e: 526.4 (M+H)+; Anal. Calc. (HCl salt) C34H44ClN3O2.0.31CHCl3: C, 68.77; H, 7.45; N, 7.01. Found: C, 68.51; H, 7.40; N, 7.39.

Provenance & Evidence