Fumarate → HCID 86737533, compound

Participants

Reaction Steps

A solution of 6.4 g (0.0186 mole) of trans-4-chloro-N-(1-ethyl-4-hyroxy-3-pyrrolidinyl)-N-phenylbenzamide base in 75 ml of ethanol was hydrogenated over 10% palladium-on-charcoal at 60° overnight. The mixture was filtered through Celite and the filtrate was concentrated. The residue was partitioned between 10% sodium hydroxide and methylene chloride. The methylene chloride layer was dried over anhydrous sodium sulfate and concentrated to give 5.6 g. (97%) of oil as residue. The oil was converted to the fumarate and the salt was recrystallized from 95% ethanol to yield an off-white powder; m.p. 191°-193° C.

Provenance & Evidence