1-(p-Chlorophenyl)cyclopropanecarboxylic acid → HCID 21957184, compound

Participants

Reaction Steps

Example 44 was prepared from 1-(4-chlorophenyl)cyclopropanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide according to the procedures described in Scheme 9: 1H NMR (400 MHz, CDCl3) δ 7.47 (s, 1H), 7.40 (s, 1H), 7.36–7.30 (m, 5H), 7.27–7.20 (m, 1H), 6.93 (d, 1H, J=7.6 Hz), 5.70–5.63 (m, 1H), 3.24 (q, 2H, J=6.6 Hz), 2.84 (d, 2H, J=11.4 Hz), 2.52 (quintet, 1H, J=7.2 Hz), 2.47–2.37 (m, 1H), 2.26 (t, 2H, J=7.2 Hz), 1.92 (t, 2H, J=11.6 Hz), 1.75 (d, 2H, J=12.5 Hz), 1.65–1.53 (m, 6H), 1.25 (d, 6H, J=7.2 Hz), 1.00 (q, 2H, J=2.9 Hz); ESMS m/e: 482.3 (M+H)+; Anal. Calc. for C28H36ClN3O2.0.540 CH2Cl3: C, 64.93; H, 7.08; N, 7.96. Found: C, 65.00; H, 7.22; N, 7.81.

Provenance & Evidence