2-(4-Fluorophenyl)propionic acid → HCID 21051137, compound

Participants

Reaction Steps

Example 46 was prepared from 2-(4-fluoro phenyl)propanoic acid and N-{5-[1-(3-aminopropyl)-4-piperidinyl]-2-fluorophenyl}-2-methyl propanamide according to the procedures described in Scheme 9: 1H NMR (400 MHz, CDCl3) δ 8.38–8.23 (m, 1H), 7.48–7.27 (m, 3H), 7.13–6.94 (m, 4H), 6.94–6.82 (m, 1H), 3.62–3.46 (m, 1H), 3.41–3.26 (m, 2H), 3.17–3.03 (m, 1H), 3.02–2.91 (m, 1H), 2.67–2.35 (m, 4H), 2.24–1.97 (m, 2H), 1.95–1.62 (m, 6H), 1.49 (d, 3H, J=7.2 Hz), 1.27 (d, 6H, J=6.8 Hz); ESMS m/e: 472.4 (M+H)+.

Provenance & Evidence