1-(4-Fluorophenyl)cyclohexane-1-carboxylic acid → N-(3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propyl)-1-(4-fluorophenyl)cyclohexanecarboxamide

Participants

Reaction Steps

Example 70 was prepared from 1-(4-fluorophenyl)cyclohexanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}acetamide according to the procedures described in Scheme 10: 1H NMR (400 MHz, CDCl3) δ 7.47 (m, 2H), 7.43–7.39 (m, 2H), 7.30–7.27 (m, 2H), 7.04–7.00 (m, 2H), 6.96 (d, 1H, J=7.2 Hz), 6.77 (br s, 1H), 3.30 (dd, 2H, J=5.6, 11.6 Hz), 2.95 (d, 2H, J=11.6 Hz), 2.49 (m, 1H), 2.34 (t, 4H, J=6.4 Hz), 2.19 (s, 3H), 1.99–1.80 (m, 6H), 1.73–1.60 (m, 10H); ESMS m/e: 480.3 (M+H)+.

Provenance & Evidence