Ethanol → HCID 70563552, compound

HRID 126925Notes

Reaction equation

HRID 126925 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH2:15][N:14]([CH:16]4[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]4)[CH2:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.C([OH:24])C>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:12][C@H:11]2[C@@H:10]([OH:9])[CH2:15][N:14]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:13]2)=[O:24])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 20288303HCID 20288303, compound

Product 1

HCID 70563552HCID 70563552, compound

Procedure

Forty-one grams of 2-(4-chlorophenyl)-5-cyclohexyl-5,6-dihydro-4H-pyrrolo-[3,4-d]oxazole was dissolved in 500 ml. of 95% ethanol and the solution was heated at reflux for one hour. The solvent was evaporated under vacuum and replaced with methylene chloride. The methyl chloride was washed with dilute sodium hydroxide, dried and evaporated. The product was crystallized from benzene. Yield was 33.2 g (94.5%); m.p. 158°-160° C.

Workup

  1. temperatureat reflux for one hour
  2. customThe solvent was evaporated under vacuum
  3. washThe methyl chloride was washed with dilute sodium hydroxide
  4. customdried
  5. customevaporated
  6. customThe product was crystallized from benzene

Sources & evidence

ORD record
ord-3dd4d2935ccc48099542662497504c6d
Source dataset
uspto-grants-1981_03
Patent number
US04254135

Reaction notes

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