1-(4-Fluorophenyl)cyclopentanecarboxylic acid → N-(3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propyl)-1-(4-fluorophenyl)cyclopentanecarboxamide

Participants

Reaction Steps

Example 72 was prepared from 1-(4-fluorophenyl) cyclopentanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}acetamide according to the procedures described in Scheme 10: 1H NMR (400 MHz, CDCl3) δ 7.44 (s, 1H), 7.38–7.25 (m, 5H), 7.03–6.97 (m, 3H), 6.49 (br s, 1H), 3.29 (dd, 2H, J=5.6, 12.0 Hz), 2.98–2.94 (m, 2H), 2.55–2.49 (m, 3H), 2.33 (t, 2H, J=6.8 Hz), 2.20 (s, 3H), 2.01–1.95 (m, 4H), 1.86–0.162 (m, 10H); ESMS m/e: 466.2 (M+H)+.

Provenance & Evidence