Triphenylacetic acid → N-(3-{4-[3-(acetylamino)phenyl]-1-piperidinyl}propyl)-2,2,2-triphenylacetamide

Participants

Reaction Steps

Example 105 was prepared from triphenylacetic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}acetamide according to the procedures described in Scheme 10: 1H NMR (400 MHz, CDCl3) δ 7.34–7.22 (m, 19H), 6.91 (d, 1H, J=7.6 Hz), 6.30 (t, 1H, J=5.6 Hz), 3.43 (dd, 2H, J=6.4, 12.0 Hz), 2.87 (d, 2H, J=12.0 Hz), 2.42 (m, 1H), 2.30 (t, 2H, J=6.8 Hz), 2.17 (s, 3H), 1.93 (t, 2H, J=11.6 Hz), 1.74–1.66(m, 4H), 1.60–1.50 (m, 2H); ESMS m/e: 546.2 (M+H)+.

Provenance & Evidence