1-(2-Chloro-4-Fluorophenyl)Cyclopentanecarboxylic Acid → HCID 21957165, compound

HRID 1269295Notes

Reaction equation

HRID 1269295 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:14]([OH:16])=O)[CH2:13][CH2:12][CH2:11][CH2:10]1.[NH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:28]=[C:29]([NH:33][C:34]([CH:36]3[CH2:38][CH2:37]3)=[O:35])[CH:30]=[CH:31][CH:32]=2)[CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:14]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([NH:33][C:34]([CH:36]4[CH2:38][CH2:37]4)=[O:35])[CH:28]=3)[CH2:23][CH2:22]2)=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 7361371-(2-Chloro-4-Fluorophenyl)Cyclopentanecarboxylic AcidHCID 21957166N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}cyclopropanecarboxamide

Product 1

HCID 21957165HCID 21957165, compound

Procedure

Example 119 was prepared from 1-(2-chloro-4-fluorophenyl)cyclopentanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}cyclopropane carboxamide according to the procedures described in Scheme 10: ESMS m/e: 526.2 (M+H)+.

Sources & evidence

ORD record
ord-c80f43f5d10f47fc9bd27e447de2bf1f
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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