2,2-Diphenylpropionic acid → N-[3-(1-{3-[(2,2-diphenylpropanoyl)amino]propyl}-4-piperidinyl)phenyl]cyclopropanecarboxamide

HRID 1269299Notes

Reaction equation

HRID 1269299 reaction equation
[C:1]1([C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([CH3:11])[C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:29]=[C:30]([NH:34][C:35]([CH:37]3[CH2:39][CH2:38]3)=[O:36])[CH:31]=[CH:32][CH:33]=2)[CH2:24][CH2:23]1>>[C:12]1([C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([CH3:11])[C:8]([NH:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([C:28]3[CH:29]=[C:30]([NH:34][C:35]([CH:37]4[CH2:39][CH2:38]4)=[O:36])[CH:31]=[CH:32][CH:33]=3)[CH2:24][CH2:23]2)=[O:10])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 796762,2-Diphenylpropionic acidHCID 21957166N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}cyclopropanecarboxamide

Product 1

HCID 21957239N-[3-(1-{3-[(2,2-diphenylpropanoyl)amino]propyl}-4-piperidinyl)phenyl]cyclopropanecarboxamide

Procedure

Example 123 was prepared from 2,2-diphenylpropanoic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}cyclopropanecarboxamide according to the procedures described in Scheme 10: ESMS m/e: 510.3 (M+H)+.

Sources & evidence

ORD record
ord-fc6d205eb33742a7b220df71101a6427
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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