2-(4-Chlorophenyl)-2-methylpropionic acid → HCID 21957243, compound

Participants

Reaction Steps

Example 127 was prepared from 2-(4-chlorophenyl)-2-methylpropanoic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-fluorophenyl}-2-methylpropanamide according to the procedures described in Scheme 9: 1H NMR (400 MHz, CDCl3) δ 7.95 (s, 1H), 7.73 (s, 1H), 7.68 (s, 1H), 7.43–7.38 (m, 1H), 7.37–7.26 (m, 3H), 6.93–6.83 (m, 2H), 3.96–3.61 (m, 1H), 3.26–3.02 (m, 4H), 2.69–2.59 (m, 1H), 2.51–2.40 (m, 2H), 1.90–1.71 (m, 4H), 1.63–1.47 (m, 4H), 1.18 (d, 6H, J=6.9 Hz), 1.15 (s, 6 H); ESMS m/e: 502.1 (M+H)+.

Provenance & Evidence