1-(2-Chloro-4-Fluorophenyl)Cyclopentanecarboxylic Acid → HCID 21957178, compound

HRID 1269313Notes

Reaction equation

HRID 1269313 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:14]([OH:16])=O)[CH2:13][CH2:12][CH2:11][CH2:10]1.[NH2:17][CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:28]=[C:29]([NH:34][C:35](=[O:39])[CH:36]([CH3:38])[CH3:37])[CH:30]=[CH:31][C:32]=2[F:33])[CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:14]([NH:17][CH2:18][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][CH:24]([C:27]3[CH:28]=[C:29]([NH:34][C:35](=[O:39])[CH:36]([CH3:38])[CH3:37])[CH:30]=[CH:31][C:32]=3[F:33])[CH2:25][CH2:26]2)=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 7361371-(2-Chloro-4-Fluorophenyl)Cyclopentanecarboxylic AcidHCID 21957238N-{3-[1-(3-aminopropyl)-4-piperidinyl]4-fluorophenyl}-2-methylpropanamide

Product 1

HCID 21957178HCID 21957178, compound

Procedure

Example 137 was prepared from 1-(2-chloro-4-fluorophenyl)cyclopentanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-fluorophenyl}-2-methylpropanamide according to the procedures described in Scheme 9: ESMS m/e: 546.1 (M+H)+.

Sources & evidence

ORD record
ord-75474b641456434c8cd4525a45ba12f2
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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