4-Methyl-alpha-(4-methylphenyl)benzeneacetic acid → Isopropyl 3-[1-(3-{[bis(4-methylphenyl)acetyl]amino}propyl)-4-piperidinyl]phenylcarbamate

Participants

Reaction Steps

Example 145 was prepared from bis(4-methylphenyl)acetic acid and isopropyl 3-[1-(3-aminopropyl)-4-piperidinyl]phenylcarbamate according to the procedures described in Scheme 9: 1H NMR (400 MHz, CDCl3) δ 7.24 (s, 1H), 7.18–7.06 (m, 4H), 7.06–7.00 (m, 6H), 6.82–6.78 (m, 2H), 6.62 (s, 1H), 4.92 (septet, 1H, J=6.7 Hz), 4.72 (s, 1H), 4.04 (q, 1H, J=6.8 Hz), 3.32–3.26 (m, 2H), 2.88–2.81 (m, 2H), 2.41–2.27 (m, 3H), 2.21 (s, 6H), 1.92–1.83 (m, 2H), 1.74–1.66 (m, 2H), 1.62–1.46 (m, 3H), 1.21 (d, 6H, J=6.7 Hz); ESMS m/e: 542.3 (M+H)+.

Provenance & Evidence