N-(3-bromopropyl)-2,2-diphenylacetamide → N-[4-(1-{3-[(2,2-diphenylacetyl)amino]propyl}-4-piperidinyl)phenyl]butanamide

HRID 1269321Notes

Reaction equation

HRID 1269321 reaction equation
Br[CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:20])[CH:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[NH:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:32]=[CH:31][C:30]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])=[CH:29][CH:28]=2)[CH2:23][CH2:22]1>>[C:8]1([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:6]([NH:5][CH2:4][CH2:3][CH2:2][N:21]2[CH2:26][CH2:25][CH:24]([C:27]3[CH:32]=[CH:31][C:30]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])=[CH:29][CH:28]=3)[CH2:23][CH2:22]2)=[O:20])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 21957140N-(3-bromopropyl)-2,2-diphenylacetamideHCID 21957274N-[4-(4-piperidinyl)phenyl]butanamide

Product 1

HCID 21957130N-[4-(1-{3-[(2,2-diphenylacetyl)amino]propyl}-4-piperidinyl)phenyl]butanamide

Procedure

Example 149 was prepared from N-(3-bromopropyl)-2,2-diphenylacetamide and N-[4-(4-piperidinyl)phenyl]butanamide according to the procedures described in Scheme 14: ESMS m/e: 498.3 (M+H)+.

Sources & evidence

ORD record
ord-d1e0707c39cc4f30a0f4488d89fddbab
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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