2,2-Diphenylacetyl chloride → N-[5-(1-{3-[(diphenylacetyl)amino]propyl}-4-piperidinyl)-2-hydroxyphenyl]-2-methylpropanamide

Participants

Reaction Steps

Example 150 was prepared from diphenylacetyl chloride and N-{5-[1-(3-aminopropyl)-4-piperidinyl]-2-hydroxyphenyl}-2-methylpropanamide according to the procedures described in Scheme 8: 1H NMR (400 MHz, CDCl3) δ 8.18 (s, 1H), 7.30–7.11 (m, 10H), 7.10–6.9 (m, 2H), 6.74 (d, 1H, J=8.3 Hz), 6.63 (dd, 1H, J=8.3, 2.0 Hz), 4.93 (s, 1H), 3.51 (t, 1H, J=5.4 Hz), 3.36 (quintet, 1H, J=6.5 Hz), 3.24–3.18 (m, 2H), 3.07–3.00 (m, 2H), 2.54–2.45 (m, 3H), 2.37–2.28 (m, 1H), 2.19–2.09 (m, 2H), 1.79–1.54 (m, 4H), 1.25 (d, 6H, J=6.8 Hz); ESMS m/e: 514.3 (M+H)+.

Provenance & Evidence