Bis(4-fluorophenyl)(hydroxy)acetic acid → N-{3-[1-(3-{[bis(4-fluorophenyl)(hydroxy)acetyl]amino}propyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide

Participants

Reaction Steps

Example 156 was prepared from bis(4-fluorophenyl)(hydroxy)acetic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide according to the procedures described in Scheme 12: 1H NMR (400 MHz, CDCl3) δ 9.44 (s, br, 1 H), 8.18 (s, 1 H), 7.62–7.48 (m, 4 H), 7.32 (s, 1 H), 7.07–7.00 (m, 1 H), 7.00–6.89 (m, 4 H), 6.72–6.53 (m, 1 H), 5.96–5.71 (br, 1 H), 3.55–3.44 (m, 2 H), 3.14–3.02 (m, 2 H), 2.83–2.66 (m, 1 H), 2.63–2.49 (m, 2 H), 2.39–2.22 (m, 1 H), 2.29 (s, 3 H), 2.17–1.98 (m, 4 H), 1.78–1.59 (m, 4 H), 0.92 (d, 6 H, J=6.8 Hz); ESMS m/e: 564.4 (M+H)+.

Provenance & Evidence