反应详情

Example 160 was prepared from bis(4-fluoro phenyl) (hydroxy)acetic acid and N-{5-[1-(3-aminopropyl)-4-piperidinyl]-2,4-difluoro phenyl}-2-methyl propanamide according to the procedures described in Scheme 12: 1H NMR (400 MHz, CDCl3) δ 9.31 (s, br, 1 H), 8.44–8.33 (m, 1 H), 7.59–7.45 (m, 4 H), 7.39 (s, 1 H), 6.97 (t, 4 H, J=8.8 Hz), 6.80 (t, 1 H, J=9.6 Hz), 5.61–5.36 (br, 1 H), 3.57–3.43 (m, 2 H), 3.14–2.99 (m, 2 H), 2.99–2.84 (m, 1 H), 2.62–2.47 (m, 2 H), 2.47–2.29 (m, 1 H), 2.14–1.93 (m, 4 H), 1.81–1.59 (m, 4 H), 0.98 (apparent t, 6 H, J=6.8 Hz); ESMS m/e: 586.3 (M+H)+.