(2S)-2-(4-fluorophenyl)propanoic acid → HCID 16756185, compound

Participants

Reaction Steps

Example 168 was prepared from (2S)-2-(4-fluorophenyl)propanoic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide according to the procedures described in Scheme 12; [α]D=+13.5° (C=1.02, MeOH): 1H NMR (400 MHz, CDCl3) δ 7.58–7.49 (m, 2 H), 7.37–7.29 (m, 2 H), 7.26–7.19 (m, 1 H), 7.06 (d, 1 H, J=8.0 Hz), 7.04–6.92 (m, 3 H), 3.56 (t, 1 H, J=6.8 Hz), 3.43–3.23 (m, 2 H), 2.95 (ABq, 2 H), 2.63–2.59 (m, 1 H), 2.59–2.45 (m, 1 H), 2.37 (t, 2 H, J=6.0 Hz), 2.27 (s, 3 H), 2.07–1.90 (m, 2 H), 1.82–1.57 (m, 6 H), 1.50 (d, 3 H, J=7.2 Hz), 1.22 (d, 6 H, J=7.2 Hz); ESMS m/e: 468.3 (M+H)+.

Provenance & Evidence