2-methyl-N-[5-(4-piperidinyl)-3-pyridinyl]propanamide → N-{5-[1-(3-{[bis(4-fluorophenyl)acetyl]amino}propyl)-4-piperidinyl]-3-pyridinyl}-2-methylpropanamide

Participants

Reaction Steps

Example 172 was prepared from N-(3-bromopropyl)-2,2-bis(4-fluoro phenyl) acetamide and 2-methyl-N-[5-(4-piperidinyl)-3-pyridinyl]propanamide according to the procedures described in Scheme 14: 1H NMR (400 MHz, CDCl3) δ 8.39 (s, 1 H), 8.19 (s, 1 H), 8.17 (S, 1 H), 7.95 (s, 1 H), 7.31–7.20 (m, 5 H), 7.04–6.94 (m, 4 H), 4.82 (s, 1 H), 3.46–3.35 (m, 2 H), 2.98–2.92 (m, 2 H), 2.62–2.48 (m, 2 H), 2.48–2.38 (m, 2 H), 2.09–1.95 (m, 2 H), 1.87–1.76 (m, 2 H), 1.76–1.55 (m, 4 H), 1.25 (d, 6 H, J=7.6 Hz); ESMS m/e: 535.4 (M+H)+.

Provenance & Evidence