2,2-Diphenylglycine → N-{3-[1-(3-{[amino(diphenyl)acetyl]amino}propyl)-4-piperidinyl]-4-fluorophenyl}cyclopropanecarboxamide

HRID 1269340Notes

Reaction equation

HRID 1269340 reaction equation
[NH2:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=O.[NH2:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:29]=[C:30]([NH:35][C:36]([CH:38]3[CH2:40][CH2:39]3)=[O:37])[CH:31]=[CH:32][C:33]=2[F:34])[CH2:24][CH2:23]1>>[NH2:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([NH:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:29]=[C:30]([NH:35][C:36]([CH:38]3[CH2:40][CH2:39]3)=[O:37])[CH:31]=[CH:32][C:33]=2[F:34])[CH2:24][CH2:23]1)=[O:5]

Participants

3

Reactant 2

HCID 182892,2-DiphenylglycineHCID 18446862N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-fluorophenyl}cyclopropanecarboxamide

Product 1

HCID 58840919N-{3-[1-(3-{[amino(diphenyl)acetyl]amino}propyl)-4-piperidinyl]-4-fluorophenyl}cyclopropanecarboxamide

Procedure

Example 174 was prepared from amino(diphenyl)acetic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-fluorophenyl}cyclopropanecarboxamide according to the procedures described in Scheme 12; ESMS m/e: 529.4 (M+H)+.

Sources & evidence

ORD record
ord-23b16bbaaa4b47d1b4b6209fbd8d2e93
Source dataset
uspto-grants-2007_04
Patent number
US07199135B2

Reaction notes

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