2-(4-Fluorophenyl)acetic acid → HCID 18446859, compound

Participants

Reaction Steps

Example 175 was prepared from (4-fluorophenyl)acetic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide according to the procedures described in Scheme 12: 1H NMR (400 MHz, CDCl3) δ 7.38 (s, 1 H), 7.32 (s, 1 H), 7.28–7.16 (m, 3 H), 7.04–6.90 (m, 3 H), 6.86 (s, 1 H), 3.47 (s, 2 H), 3.27 (q, 2 H, J=6.0 Hz), 2.95 (d, 2 H, J=11.6 Hz), 2.69–2.53 (m, 1 H), 2.50–2.32 (m, 3 H), 2.19 (s, 3 H), 2.09–1.94 (m, 2 H), 1.74–1.53 (m, 6 H), 1.15 (d, 6 H, J=7.2 Hz); ESMS m/e: 454.3 (M+H)+.

Provenance & Evidence