HCID 20288513, compound → HCID 15634751, compound

Participants

Reaction Steps

A solution of 6.9 g (0.017 mol) of 2-[3-(4-chlorobenzoyl)-2-nitrophenyl]propanedioic acid in 40 ml of 20% sulfuric acid and 40 ml of acetic acid was heated at reflux under a nitrogen atmosphere overnight. The reaction mixture was cooled, and the solid which precipitated was collected by filtration and stirred with 150 ml of 5% sodium bicarbonate. The mixture was filtered and the filtrate was made acidic with concentrated sulfuric acid. The resulting white solid was collected by filtration and recrystallized from aqueous isopropyl alcohol to yield 3.2 g (61%) of white needles, m.p. 164°-165° C.

Provenance & Evidence