反应详情

To a solution of 79 g of 3-(hydroxymethyl)phenol in 300 mL of DMF cooled at 0° C. was added 50 g of imidazole followed by 101 g of tert-butyl(chloro)dimethylsilane. The reaction was warmed to rt and stirred overnight. The reaction was quenched with aqueous NH4Cl, extracted with EtOAc and washed with brine, dried over sodium sulfate, evaporated, and purified by flash chromatography (10–30% EtOAc/hexane) to afford 140 g of the title compound as a yellow oil.

1. customThe reaction was quenched with aqueous NH4Cl
2. extractionextracted with EtOAc
3. washwashed with brine
4. dry with materialdried over sodium sulfate
5. customevaporated
6. custompurified by flash chromatography (10–30% EtOAc/hexane)