2272-29-9 → HCID 10156349, compound

HRID 1269371Notes

Reaction equation

HRID 1269371 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[N:3]=1.[CH2:17]1[O:26][C:25]2[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][C:19]=2[O:18]1>>[O:26]1[C:25]2[CH:24]=[CH:23][C:21]([NH:22][C:2]3[N:3]=[C:4]([NH:9][C:10]4[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=4)[N:5]=[C:6]([Cl:8])[N:7]=3)=[CH:20][C:19]=2[O:18][CH2:17]1

Participants

3

Reactant 2

HCID 167632272-29-9HCID 843101,3-Benzodioxol-5-amine

Product 1

HCID 10156349HCID 10156349, compoundYield 65%

Procedure

The reaction of 4,6-dichloro-N-(4-chlorophenyl)-[1,3,5]triazine-2-amine with 3,4-methylenedioxyaniline using the method described for the synthesis of CT-116433 provided CT-31978 (56 mg, 65% yield). 1H NMR (d6-DMSO) δ 10.08–10.37 (m, 2H), 7.58–7.87 (m, 2H), 7.21–7.40 (m, 3H), 6.85–7.03 (m, 2H), 6.00 (s, 2H).

Workup

  1. customdescribed for the synthesis
  2. customof CT-116433 provided CT-31978 (56 mg, 65% yield)

Sources & evidence

ORD record
ord-77fc953d6ac4488e90db77e367d76bca
Source dataset
uspto-grants-2007_04
Patent number
US07199238B2

Reaction notes

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