Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1269377Generated: October 26, 2026

p-Toluenesulfonic acid → 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methoxymethylideneamino-4-trifluoromethylsulfinylpyrazole

https://huagongshe.com/reaction/1269377

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Toluenesulfonic acidHCID 6101—
ReactantTrimethyl orthoformateHCID 9005—
ReactantHCID 178510672HCID 178510672—
Product3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methoxymethylideneamino-4-trifluoromethylsulfinylpyrazoleHCID 72782804—

Reaction Steps

A substantial molar excess of trimethylorthoformat is reacted with fipronil (Compound IV) at reflux with 0.5 equivalents of paratoluensulfonic acid to provide 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methoxymethylideneamino-4-trifluoromethylsulfinylpyrazole (Compound III).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07199246B2
Source datasetuspto-grants-2007_04
ORD IDord-73fbe05f322e4fe9a0a038e2fd9f4b19
Source noteuspto-grants-2007_04