Acetone → HCID 23457770, compound

HRID 126938Notes

Reaction equation

HRID 126938 reaction equation
Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].CC(C)=O.[CH3:32][C:33]([CH3:37])([OH:36])[C:34]#[N:35]>N1C=CC=CC=1>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([O:36][C:33]([C:34]#[N:35])([CH3:37])[CH3:32])=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

5

Reactant 3

HCID 180AcetoneHCID 6406Acetone CyanohydrinHCID 132553224-Hexadecylaminobenzoyl chloride hydrochloride

Product 1

HCID 23457770HCID 23457770, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A stirred solution of 20 g. (48.0 m moles) 4-(hexadecylamino)benzoyl chloride hydrochloride in 500 ml. acetone and 50 ml. pyridine is cooled in an ice-water bath, and to this in portions is added 4.3 g. (51 m moles) acetone cyanohydrin. The solution is warmed to room temperature and stirred for an additional two hours. The solvents are evaporated to a yellow gum, which crystallizes to off-white crystals from ethanol.

Workup

  1. additionto this in portions is added 4.3 g
  2. customThe solvents are evaporated to a yellow gum, which
  3. customcrystallizes to off-white crystals from ethanol

Sources & evidence

ORD record
ord-9bf6a7a82df3451488cb9ef8ef53ce55
Source dataset
uspto-grants-1981_03
Patent number
US04254138

Reaction notes

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