Triethylamine → HCID 18448528, compound

Participants

Reaction Steps

To a solution of 2-piperidin-2-yl-N-[6-(1-piperidin-1-ylmethyl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetamide (155.8 mg, 0.39 mmol) in CH2Cl2(2 mL) was added 3-(trifluoromethyl)benzenesulfonyl chloride (Fluka, 0.1 mL, 0.59 mmol) and Et3N (Aldrich, 0.1 mL, 0.79 mmol). The mixture was stirred at rt overnight, diluted with CH2Cl2 (30 mL), washed with 10% Na2CO3 (twice) and brine. The organic solution was dried over Na2SO4, filtered and concentrated in vacuo. The crude was purified by silica gel chromatography (3%–10% MeOH—CH2Cl2) to provide the title compound. MS (ESI): 604 (M+H)+. Calc'd for C32H40F3N3O3S—603.27.

Provenance & Evidence