HCID 18448528, compound → HCID 69431308, compound

Participants

Reaction Steps

A mixture of N-[6-(1-piperidin-1-ylmethyl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-2-[1-(3-trifluoromethyl-benzenesulfonyl)-piperidin-2-yl]-acetamide (34 mg, 0.05 mmol), EtOH (2 mL), Pd/Al2O3 (Johnson Matthey, 12 mg, 0.1 eq) was purged with H2 and connected to a H2 balloon for 30 min at RT. The catalyst was filtered through Celite and washed with MeOH. The filtrate was concentrated in vacuo. The crude was purified by silica gel chromatography (7%–10% MeOH—CH2Cl2) to afford the title compound as a mixture of two diastereomers. MS (ESI): 606 (M+H)+. Calc'd for C32H42F3N3O3S—605.29.

Provenance & Evidence