Triethylamine → 2-(S)-(+)-(5-bromo-6-methoxy-2-naphthyl)propanoic acid, 4-(nitrooxy)butyl ester

HRID 1269465노트

반응식

HRID 1269465 반응식
C(N(CC)CC)C.[Br:8][C:9]1[C:18]([O:19][CH3:20])=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][C:13]([C@H:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:14]2.Br[CH2:27][CH2:28][CH2:29][CH2:30][O:31][N+:32]([O-:34])=[O:33]>CN(C=O)C>[Br:8][C:9]1[C:18]([O:19][CH3:20])=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][C:13]([C@H:21]([CH3:25])[C:22]([O:24][CH2:27][CH2:28][CH2:29][CH2:30][O:31][N+:32]([O-:34])=[O:33])=[O:23])=[CH:14]2

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 104202524-Bromobutyl nitrateHCID 115296645-Bromonaproxen, (S)-

생성물 1

HCID 99541792-(S)-(+)-(5-bromo-6-methoxy-2-naphthyl)propanoic acid, 4-(nitrooxy)butyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of triethylamine (5.25 g, 52 mmol), of 2-(S)-(5-bromo-6-methoxy-2-naphthyl)propanoic acid (Bromo-Naproxen) (13.3 g, 43 mmol); e.e.99%) and of 4-bromobutylnitrate (43 mmol) in DMF (120 ml) was stirred under nitrogen for 2 days at 25° C.

출처 및 근거

ORD 기록
ord-17f71f54eab14fa08f2232e323ddbc8f
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07199258B2

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