反应详情

10% Palladium on carbon (10 mg, 10 wt %) was added to a solution of 2-(3-{1-[3-(4-Isopropyl-phenyl)-acryloyl]-piperidin-3-yl}-phenoxy)-2-methyl-propionic acid benzyl ester (89 mg, 0.17 mmol) in methanol (2 mL) and the resulting mixture hydrogenated at atmospheric pressure for 3 h. The reaction mixture was filtered through a plug of celite and the celite plug washed thoroughly with ethyl acetate. The combined filtrates were concentrated under reduced pressure to provide 73 mg (99%) of 2-(3-{1-[3-(4-Isopropyl-phenyl)-propionyl]-piperidin-3-yl}-phenoxy)-2-methyl-propionic acid as a clear oil.

1. filtrationThe reaction mixture was filtered through a plug of celite
2. washthe celite plug washed thoroughly with ethyl acetate
3. concentrationThe combined filtrates were concentrated under reduced pressure