反应详情

10% Palladium on carbon (180 mg, 10 wt %) was added to a solution of 3-[3-(1-Benzyloxycarbonyl-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid 4-isopropyl-phenyl ester (1.76 g, 3.41 mmol) in methanol (15 mL) and the resulting mixture hydrogenated at atmospheric pressure for 3 h. The reaction mixture was filtered through a plug of celite and the celite plug washed thoroughly with ethyl acetate. The combined filtrates were concentrated under reduced pressure to provide 1.26 g (87%) of: 3-[3-(1-Carboxy-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid 4-isopropyl-phenyl ester as a clear oil.

1. filtrationThe reaction mixture was filtered through a plug of celite
2. washthe celite plug washed thoroughly with ethyl acetate
3. concentrationThe combined filtrates were concentrated under reduced pressure