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Cuminol → Imidazole-1-carboxylic acid-(4-isopropyl)benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cuminol | HCID 325 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Imidazole-1-carboxylic acid-(4-isopropyl)benzyl ester | HCID 18448505 | 87.4% |
反応手順
To a solution of 4-isopropylbenzyl alcohol (4.51 g, 30.02 mmol) in 50 mL toluene was added 1,1′-carbonyldiimidazole (4.87 g, 30.02 mmol). This solution was stirred 18 h at ambient temperature. White precipitate was filtered off and the filtrate was concentrated under reduced pressure. The resultant oil was flash chromatographed with 15% ethyl acetate/hexanes to yield 6.41 g (87%) of imidazole-1-carboxylic acid-(4-isopropyl)benzyl ester, a clear oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07199243B2 |
| 出典データセット | uspto-grants-2007_04 |
| ORD ID | ord-1685956851ef457384e661d9331fbdf2 |
| 出典メモ | uspto-grants-2007_04 |