Hydrochloric Acid → HCID 68883845, compound

Participants

Reaction Steps

(S)-2-methyl-2-(3-piperidin-3-yl-phenoxy)-propionic acid benzyl ester-L-(+)-tartrate salt (Preparation 3, Method F; 119 mg, 0.24 mmol) was dissolved in 2 mL methlyene chloride and 1 mL water. Sodium bicarbonate (79 mg, 0.95 mmol) and methyl chloroformate (37 mL, 0.47 mmol) were added, and the biphasic mixture and resulting mixture stirred at ambient temperature for 2 h. The mixture was diluted with water (50 mL), acidified with 1N aqueous hydrochloric acid and extracted with diethyl ether (2×50 mL). The combined organic extracts were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to provide 90 mg (93%) of (S)-3-[3-(1-Benzyloxycarbonyl-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid methyl ester as a clear oil.

Provenance & Evidence