HCID 68883845, compound → HCID 68884356, compound

Participants

Reaction Steps

10% Palladium on carbon (18 mg, 10 wt %) was added to a solution of (S)-3-[3-(1-Benzyloxycarbonyl-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid methyl ester (90 mg, 0.22 mmol) in methanol (3 mL) and the resulting mixture hydrogenated at atmospheric pressure for 3 h. The reaction mixture was filtered through a plug of celite and the celite plug washed thoroughly with ethyl acetate. The combined filtrates were concentrated under reduced pressure to provide 65 mg (92%) of (S)-3-[3-(1-carboxy-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid methyl ester as a clear oil.

Provenance & Evidence