Isobutyryl chloride → HCID 86592328, compound

Participants

Reaction Steps

Methyl[3,5-dichloro-4-(4-aminophenoxy)phenyl] acetate (33 mg, 0.10 mmol), was coupled with isobutyryl chloride (11 mg), using the method described in Example 1(h). After purification on column (silica gel, ethyl acetate/petrolium ether), 35 mg (95%) of methyl-[3,5-dichloro-4-(4-isobutyramidophenoxy)phenyl] acetate was obtained, which was hydrolysed using the method described in Example 1(i). This gave 30 mg (89%) of 3,5-dichloro-4-(4-isobutyramidophenoxy)phenylacetic acid.

Provenance & Evidence