Tetramethyltin → HCID 10178849, compound

Participants

Reaction Steps

Methyl[3,5-dichloro-4-(3-bromo-4-isobutyramidophenoxy)phenyl] acetate (100 mg) was reacted with tetramethyltin (40 mg), dichloro(1,2-bis(diphenylphosphino)butane)palladium(II), copper(II) oxide (16 mg) and dimethylformamide (3 mL) using the method described in Example 3. This gave 20 mg (23%) of methyl(3,5-dichloro-4-[4-isobutyr-amido-3-methylphenoxy]phenyl) acetate, which was hydrolyzed using the method described in Example 1(i), to give 17 mg (88%) of 3,5-dichloro-4-(4-isobutyramido-3-methyl-phenoxy)phenylacetic acid, m/z 396.

Provenance & Evidence