Potassium Carbonate → HCID 18448757, compound

Participants

Reaction Steps

A mixture of 4-bromo-2,6-dichlorophenol (2.4 g), 5-fluoro-2-nitro-trifluoromethylbenzene (2.0 g), potassium carbonate (2.7 g) in dimethylformamide (30 mL) was heated at reflux for 2 hours. The reaction was cooled to room temperature and concentrated. The residue was partioned between ethyl acetate and hydrochloric acid (2 N), the organic phase concentrated and the residue purified on column (silica gel, ethyl acetate/petrolium ether, 5:95), to give 2.7 g of 3,5-dichloro-4-(4-nitro-3-trifluoromethylphenoxy)bromo-benzene.

Provenance & Evidence