Calcium hypochlorite → HCID 86760481, compound

Participants

Reaction Conditions

Reaction Steps

Calcium hypochlorite (14 mg) was dissolved in a mixture of water (2 mL) and glacial acetic acid (one drop). Methyl[3,5-dichloro-4-(4-aminophenoxy)phenyl] acetate (35 mg) dissolved in acetone (2 mL) was added at −10° C. After stirring at −15° C. for 2 hours, the reaction mixture was concentrated and the residue partioned between sodium hydroxide (1 N) and ethyl acetate. After purification on column (silica gel, ethyl acetate/petrolium ether, 1:4), 17 mg (43%) of methyl[3,5-dichloro-4-(4-amino-3-chlorophenoxy)phenyl] acetate was obtained.

Provenance & Evidence