Isobutyryl chloride → HCID 86760482, compound

Participants

Reaction Steps

Methyl[3,5-dichloro-4-(4-amino-3-chlorophenoxy)phenyl] acetate (17 mg) was coupled with isobutyryl chloride (5.0 mg), using the method described in Example 1(h). After purification on column (silica gel, ethyl acetate/petrolium ether, 1:4), 15 mg (74%) of methyl(3,5-dichloro-4-[3-chloro-4-isobutyramidophenoxy]phenyl) acetate was obtained, which was hydrolysed using the method described in Example 1(i). This gave 4 mg (27%) of 3,5-dichloro-4-(4-isobutyramido-3-trifluoromethylphenoxy)phenylacetic acid, m/z 416, 418.

Provenance & Evidence