2-Chloropropionyl chloride → HCID 86592338, compound

Participants

Reaction Steps

Ethyl(3,5-dichloro-4-[4-amino-3-bromophenoxy]phenyl) cinnamate (70 mg) was coupled with 2-chloropropionyl chloride (30 mg), using the method described in Example 1(h). After purification on column (silica gel, ethyl acetate/petrolium ether, 1:9), 45 mg (83%) of ethyl(3,5-dichloro-4-[3-bromo-4-(2-chloropropionamido)phenoxy]phenyl) cinnamate was obtained. A part of the ethyl ester (50 mg) was hydrolysed using the method described in Example 1(i), to give 40 mg (84%) of 3,5-dichloro-4-(3-bromo-4-[2-chloropropionamido]-phenoxy)phenylcinnamic acid.

Provenance & Evidence